Combination of isoform-selective histone/protein deacetylase inhibitors improves Foxp3+ T-regulatory cell function
نویسندگان
چکیده
Comment on: Beier UH, et al. Sci Signal 2012; 5:ra45.
منابع مشابه
Combination of IL-2, rapamycin, DNA methyltransferase and histone deacetylase inhibitors for the expansion of human regulatory T cells
FOXP3+ regulatory T cell (Treg) based cellular therapies represent promising therapeutic options in autoimmunity, allergy, transplantation and prevention of Graft Versus Host (GVH) Disease. Among human FOXP3-expressing CD4+T cells, only the CD45RA+ naïve Treg (nTreg) subset is suitable for in vitro expansion. However, FoxP3 expression decays in cells using currently described culture protocols....
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